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Journal Article

Drosophila Pax-6/eyeless is essential for normal adult brain structure and function.

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons84975

Strauss,  R
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Callaerts, P., Leng S, Clements J, Clements J, Cribbs D, Kang YY, Walldorf U, Fischbach, K., & Strauss, R. (2001). Drosophila Pax-6/eyeless is essential for normal adult brain structure and function. Journal of Neurobiology, 46, 73-88.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-E326-6
Abstract
A role for the Pax-6 homologue eyeless in adult Drosophila brain development and function is described. eyeless expression is detected in neurons, but not glial cells, of the mushroom bodies, the medullar cortex, the lateral horn, and the pars intercerebralis. Furthermore, severe defects in adult brain structures essential for vision, olfaction, and for the coordination of locomotion are provoked by two newly isolated mutations of Pax-6/eyeless that result in truncated proteins. Consistent with the morphological lesions, we observe defective walking behavior for these eyeless mutants. The implications of these data for understanding postembryonic brain development and function in Drosophila are discussed.