Help Guide Disclaimer Contact us Login
  Advanced SearchBrowse




Journal Article

Slow clearance gadolinium-based extracellular and intravascular contrast media for three-dimensional MR angiography


Colet JM, Giovenzana GB, Aime S, Scheffler,  K
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

There are no locators available
Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available

Bremerich, J., Colet JM, Giovenzana GB, Aime S, Scheffler, K., Laurent S, Bongartz, G., & Muller, R. (2001). Slow clearance gadolinium-based extracellular and intravascular contrast media for three-dimensional MR angiography. Journal of Magnetic Resonance Imaging, 13(4), 588-593. doi:10.1002/jmri.1082.

Cite as:
The objective of this study was to assess two new slow-clearance contrast media with extracellular and intravascular distribution for magnetic resonance angiography (MRA). Extracellular Gd-DTPA-BC2glucA and intravascular Gd(DO3A)3-lys16 were developed within the European Biomed2 MACE Program and compared with two reference compounds, intravascular CMD-A2-Gd-DOTA and extracellular GdDOTA, in 12 rats. Pre- and post-contrast three-dimensional MR (TR/TE = 5 msec/2.2 msec; isotropic voxel size 0.86 mm3) was acquired for 2 hours. Signal-to-noise enhancement (ΔSNR) was calculated. Two minutes after injection, all contrast media provided strong vascular signal enhancement. The ΔSNR for Gd-DTPA-BC2glucA, Gd(DO3A)3-lys16, CMD-A2-Gd-DOTA, and GdDOTA were 13.0 ± 1.8, 25.0 ± 3.2, 25.0 ± 4.0, and 18.0 ± 3.4, respectively. Gd-DTPA-BC2glucA, Gd(DO3A)3-lys16, and CMD-A2-Gd-DOTA cleared slowly from the circulation, whereas GdDOTA cleared rapidly. Vascular ΔSNR at 2 hours were 2.9 ± 0.6, 25.0 ± 3.2, 25.0 ± 4.0, and 0.4 ± 1.0. Gd(DO3A)3-lys16 provided strong vascular and minor background enhancement, and thus may be useful for MRA or perfusion imaging. Gd-DTPA-BC2glucA produces persistent enhancement of extracellular water, and thus may allow quantification of extracellular distribution volume and assessment of myocardial viability.