Frontocortical N-acetylaspartate reduction associated with long-term IV heroin 
use

Haselhorst, R; Dürsteler-MacFarland, KM; Scheffler, K; Ladewig, D; Müller-Spahn, F; Stohler, R; Seelig, J; Seifritz, E

doi:10.1212/WNL.58.2.305

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Frontocortical N-acetylaspartate reduction associated with long-term IV heroin use

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https://n.neurology.org/content/58/2/305
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Haselhorst, R., Dürsteler-MacFarland, K., Scheffler, K., Ladewig, D., Müller-Spahn, F., Stohler, R., et al. (2002). Frontocortical N-acetylaspartate reduction associated with long-term IV heroin use. Neurology, 58(2), 305-307. doi:10.1212/WNL.58.2.305.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-E064-5

Abstract

To examine possible metabolic frontal lobe alterations in IV heroin-dependent patients with different histories of concomitant substance use, N-acetylaspartate (NAA), a putative marker of neuronal viability, was measured by 1H-MRS. Compared with controls, NAA levels in patients were reduced by 7 in gray matter (p = 0.015) but not in white matter. To what extent comorbid conditions or substance use, including alcohol, contributed to these frontocortical metabolic changes remains to be elucidated.