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The role of astroglia on the survival of dopamine neurons

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons84751

de Bernardo S, Casarejos MJ, Canals,  S
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Zitation

Mena, M., de Bernardo S, Casarejos MJ, Canals, S., & Rodríguez-Martín, E. (2002). The role of astroglia on the survival of dopamine neurons. Molecular Neurobiology, 25(3), 245-263. doi:10.1385/MN:25:3:245.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0013-DFA4-F
Zusammenfassung
Glial cells play a key role in the function of dopamine (DA) neurons and regulate their differentiation, morphology, physiological and pharmacological properties, survival, and resistance to different models of DA lesion. Several studies suggest that glial cells may be important in the pathogenesis of Parkinson’s disease (PD), a common neurodegenerative disorder characterized by degeneration of the nigrostriatal DA system. In this disease the role of glia could be due to the excessive production of toxic products such as nitric oxide (NO) or cytokines characteristic of inflammatory process, or related to a defective release of neuroprotective agents, such as small antioxidants with free radical scavenging properties or peptidic neurotrophic factors.