de.mpg.escidoc.pubman.appbase.FacesBean
English
 
Help Guide Disclaimer Contact us Login
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Co-Clustering of Biological Networks and Gene Expression Data

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons84331

Zien,  A
Department Empirical Inference, Max Planck Institute for Biological Cybernetics, Max Planck Society;

Locator
There are no locators available
Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available
Citation

Hanisch, D., Zien, A., Zimmer, R., & Lengauer, T. (2002). Co-Clustering of Biological Networks and Gene Expression Data. Bioinformatics, (Suppl 1), 145S-154S. Retrieved from http://bioinformatics.oupjournals.org/cgi/content/abstract/18/suppl_1/S145.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-DF7E-7
Abstract
Motivation: Large scale gene expression data are often analysed by clustering genes based on gene expression data alone, though a priori knowledge in the form of biological networks is available. The use of this additional information promises to improve exploratory analysis considerably. Results: We propose constructing a distance function which combines information from expression data and biological networks. Based on this function, we compute a joint clustering of genes and vertices of the network. This general approach is elaborated for metabolic networks. We define a graph distance function on such networks and combine it with a correlation-based distance function for gene expression measurements. A hierarchical clustering and an associated statistical measure is computed to arrive at a reasonable number of clusters. Our method is validated using expression data of the yeast diauxic shift. The resulting clusters are easily interpretable in terms of the biochemical network and the gene expression data and suggest that our method is able to automatically identify processes that are relevant under the measured conditions.