Enantioselective oxidation of racemic 1,2-propanediol to D-(−)-lactic acid by 
Gluconobacter oxydans

Su, W; Chang, Z; Gao, K; Wei, D

doi:10.1016/j.tetasy.2004.03.009

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Enantioselective oxidation of racemic 1,2-propanediol to D-(−)-lactic acid by Gluconobacter oxydans

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https://www.sciencedirect.com/science/article/pii/S0957416604001879
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Su, W., Chang, Z., Gao, K., & Wei, D. (2004). Enantioselective oxidation of racemic 1,2-propanediol to D-(−)-lactic acid by Gluconobacter oxydans. Tetrahedron: Asymmetry, 15(8), 1275-1277. doi:10.1016/j.tetasy.2004.03.009.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-D975-3

Abstract

Gluconobacter oxydans DSM 2003 was firstly used in the production of (R)-2-hydroxy-propionic acid through microbial oxidation of racemic 1,2-propanediol. The biotransformation was processed with high enantiomeric excess (>99) and near theoretical yield (48 of racemic 1,2-propanediol) when the substrate concentration was lower than 20 g/L. When the substrate concentration was increased, maintaining the pH at 6.0 helped to improve the enantioselectivity.