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V1 cortical reorganization revisited: fMRI and electrophysiology in macaque following retinal lesions

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons84972

Smirnakis,  SM
Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84190

Brewer AA, Schmid,  M
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84260

Tolias,  AS
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons83787

Augath,  M
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84202

Inhoffen W, Schüz,  A
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84063

Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Smirnakis, S., Brewer AA, Schmid, M., Tolias, A., Augath, M., Inhoffen W, Schüz, A., Wandell, B., et al. (2004). V1 cortical reorganization revisited: fMRI and electrophysiology in macaque following retinal lesions. Talk presented at 34th Annual Meeting of the Society for Neuroscience (Neuroscience 2004). San Diego, CA, USA.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-D7D1-3
Abstract
ntroduction. Electrophysiological studies (Chino, Calford, Heinen, Gilbert, Kaas, Rosa) suggest that adult V1 visual field maps reorganize after de-afferentiation. The reported electrophysiological reorganization appears inconsistent with cytochrome oxidase staining patterns after similar de-afferentiation (Horton amp;amp; Hocking, J Neurosci 1998). We are measuring macaque V1 responses with functional magnetic resonance imaging (fMRI) and electrophysiology to clarify the extent of V1 reorganization. Methods. A retinal photocoagulation laser (GYC-2000, NIDEK) was used to lesion 5-8 degree homonymous visual field locations in four adult rhesus macaques. The retinal lesion creates a de-afferentiated V1 zone referred to as the lesion projection zone, or LPZ (Schmid et al., Cerebral Cortex 1996). As expected, following the lesion we found little or no response to visual stimulation inside the LPZ using functional magnetic resonance imaging (fMRI) at 4.7T in the anesthetized macaque preparation (Logothetis et al., Nat Neurosci 1999). The extent of V1 reorganization was quantified by repeatedly measuring the visual modulation in the BOLD signal near the border of the LPZ. Results. Over the course of seven months, we found very little, if any, increase in BOLD activity within the LPZ apart from that expected by reduced retinal swelling. The boundary of the LPZ remained stable to within 1 mm. The stable scotoma persisted in the BOLD response in all four animals tested. Parallel electrophysiological experiments are in progress in these animals, allowing direct comparison between BOLD measurements and single unit responses.