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Functionalized azamacrocyclic compounds as Ca2+ sensitive contrast agents for MR imaging

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons84074

Mamedov,  I
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84137

Pfeuffer,  J
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84063

Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Mamedov, I., Pfeuffer, J., Logothetis, N., & Mayer, H. (2005). Functionalized azamacrocyclic compounds as Ca2+ sensitive contrast agents for MR imaging. Poster presented at XXX. International Symposium on Macrocyclic Chemistry (ISMC 2005), Dresden, Germany.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-D537-F
Abstract
The ability to non-invasively observe changes in Ca2+ concentration is important for neuroscience. We have therefore developed a series of gadolinium chelate complexes based on DO3A (Scheme 1), which is hypothesized to change relaxivity in magnetic resonance experiments dynamically with Ca2+ concentration. Different lengths of the phosphonate side chains are expected to lead to different binding constants of the phosphonate - gadolinium bonds. The latter property can be exploited for fine-tuning the sensitivity of the agent to calcium ion concentration.