Item

ITEM ACTIONS

This item is discarded!DetailsSummary

Discarded

Journal Article

Correlation of EEG spectral entropy with regional cerebral blood flow during sevoflurane and propofol anaesthesia

MPS-Authors

/persons/resource/persons84076

Kaisti K, Aalto S, Mäenpää M, Jääskeläinen S, Hinkka S, Martens, SMM
Department Empirical Inference, Max Planck Institute for Biological Cybernetics, Max Planck Society;

External Resource

No external resources are shared

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Maksimow, A., Kaisti K, Aalto S, Mäenpää M, Jääskeläinen S, Hinkka S, Martens, S., Särkelä M, Viertiö-Oja, H., & Scheinin, H. (2005). Correlation of EEG spectral entropy with regional cerebral blood flow during sevoflurane and propofol anaesthesia. Anaesthesia, 60(9), 862-869. doi:10.1111/j.1365-2044.2005.04289.x.

Abstract

ENTROPY index monitoring, based on spectral entropy of the electroencephalogram, is a promising new method to measure the depth of anaesthesia. We examined the association between spectral entropy and regional cerebral blood flow in healthy subjects anaesthetised with 2, 3 and 4 end-expiratory concentrations of sevoflurane and 7.6, 12.5 and 19.0 microg.ml(-1) plasma drug concentrations of propofol. Spectral entropy from the frequency band 0.8-32 Hz was calculated and cerebral blood flow assessed using positron emission tomography and [(15)O]-labelled water at baseline and at each anaesthesia level. Both drugs induced significant reductions in spectral entropy and cortical and global cerebral blood flow. Midfrontal-central spectral entropy was associated with individual frontal and whole brain blood flow values across all conditions, suggesting that this novel measure of anaesthetic depth can depict global changes in neuronal activity induced by the drugs. The cortical areas of the most significant associations were remarkably similar for both drugs.