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Physicochemical Characterization of the Strychnos Alkaloids by Capillary Zone Electrophoresis

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons84329

Zhang F, Zhang,  X
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84802

Xu Q, Xiao,  H
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Fu, S., Zhang F, Zhang, X., Xu Q, Xiao, H., & Liang, X. (2005). Physicochemical Characterization of the Strychnos Alkaloids by Capillary Zone Electrophoresis. Analytical Sciences, 21(11), 1303-1308.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-D399-7
Abstract
A capillary zone electrophoresis (CZE) method has been developed for investigating the physicochemical characteristics of five Strychnos alkaloids in Strychnos nux-vomica L. Firstly, the dissociation constants of the five Strychnos alkaloids were determined, based on the relation between the effective mobility of the solutes and the buffer pH. The mathematical relationship was strictly deduced from the fundamental electrophoretic theory and the dissociation equilibrium. Secondly, an equation describing the relation between the migration time of alkaloids of similar structure and their molecular weights was developed and used to predict the migration order and to calculate the electrosomotic velocity. The results predicted by the theory agreed with those from experiments.