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Mapping Cortical Activity Elicited with Electrical Microstimulation Using fMRI in the Macaque

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons84260

Tolias,  AS
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons83787

Sultan F, Augath,  MA
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84733

Oeltermann,  A
Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84063

Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Zitation

Tolias, A., Sultan F, Augath, M., Oeltermann, A., Tehovnik EJ, Schiller, P., & Logothetis, N. (2005). Mapping Cortical Activity Elicited with Electrical Microstimulation Using fMRI in the Macaque. Neuron, 48(6), 901-911. doi:10.1016/j.neuron.2005.11.034.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0013-D36B-F
Zusammenfassung
Over the last two centuries, electrical microstimulation has been used to demonstrate causal links between neural activity and specific behaviors and cognitive functions. However, to establish these links it is imperative to characterize the cortical activity patterns that are elicited by stimulation locally around the electrode and in other functionally connected areas. We have developed a technique to record brain activity using the blood oxygen level dependent (BOLD) signal while applying electrical microstimulation to the primate brain. We find that the spread of activity around the electrode tip in macaque area V1 was larger than expected from calculations based on passive spread of current and therefore may reflect functional spread by way of horizontal connections. Consistent with this functional transynaptic spread we also obtained activation in expected projection sites in extrastriate visual areas, demonstrating the utility of our technique in uncovering in vivo functional connectivity maps.