Help Guide Disclaimer Contact us Login
  Advanced SearchBrowse




Journal Article

18F-Choline Images Murine Atherosclerotic Plaques Ex Vivo


Wyss M, Spath N, von Lukowicz T, Lohmann C, Weber,  B
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

There are no locators available
Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available

Matter, C., Wyss M, Spath N, von Lukowicz T, Lohmann C, Weber, B., de Molina AR, Ametamey SM, von Schulthess GK, Kaufmann, P., & Buck, A. (2006). 18F-Choline Images Murine Atherosclerotic Plaques Ex Vivo. Arteriosclerosis, Thrombosis, and Vascular Biology, 26(3), 584-589. doi:10.1161/01.ATV.0000200106.34016.18.

Cite as:
Objective— Current imaging modalities of atherosclerosis mainly visualize plaque morphology. Valuable insight into plaque biology was achieved by visualizing enhanced metabolism in plaque-derived macrophages using 18F-fluorodeoxyglucose (18F-FDG). Similarly, enhanced uptake of 18F-fluorocholine (18F-FCH) was associated with macrophages surrounding an abscess. As macrophages are important determinants of plaque vulnerability, we tested 18F-FCH for plaque imaging. Methods and Results— We injected 18F-FCH (n=5) or 18F-FDG (n=5) intravenously into atherosclerotic apolipoprotein E-deficient mice. En face measurements of aortae isolated 20 minutes after 18F-FCH injections demonstrated an excellent correlation between fat stainings and autoradiographies (r=0.842, P