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Journal Article

18F-Choline Images Murine Atherosclerotic Plaques Ex Vivo

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Wyss M, Spath N, von Lukowicz T, Lohmann C, Weber, B
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Matter, C., Wyss M, Spath N, von Lukowicz T, Lohmann C, Weber, B., de Molina AR, Ametamey SM, von Schulthess GK, Kaufmann, P., & Buck, A. (2006). 18F-Choline Images Murine Atherosclerotic Plaques Ex Vivo. Arteriosclerosis, Thrombosis, and Vascular Biology, 26(3), 584-589. doi:10.1161/01.ATV.0000200106.34016.18.

Abstract

Objective Current imaging modalities of atherosclerosis mainly visualize plaque morphology. Valuable insight into plaque biology was achieved by visualizing enhanced metabolism in plaque-derived macrophages using 18F-fluorodeoxyglucose (18F-FDG). Similarly, enhanced uptake of 18F-fluorocholine (18F-FCH) was associated with macrophages surrounding an abscess. As macrophages are important determinants of plaque vulnerability, we tested 18F-FCH for plaque imaging. Methods and Results We injected 18F-FCH (n=5) or 18F-FDG (n=5) intravenously into atherosclerotic apolipoprotein E-deficient mice. En face measurements of aortae isolated 20 minutes after 18F-FCH injections demonstrated an excellent correlation between fat stainings and autoradiographies (r=0.842, P