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Intracellular MR Contrast Agents Based on Cationic Cell Penetrating Peptides: A Comparative Study

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons83903

Engelmann,  J
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84244

Su,  W
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons83995

Jha,  D
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84085

Mishra,  R
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84137

Pfeuffer,  J
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Engelmann, J., Su, W., Jha, D., Mishra, R., Pfeuffer, J., & Ugurbil, K. (2006). Intracellular MR Contrast Agents Based on Cationic Cell Penetrating Peptides: A Comparative Study. Poster presented at 14th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2006), Seattle, WA, USA.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-D201-5
Abstract
For the development of intracellular Magnetic Resonance contrast agents (CAs) it is a prerequisite that they cross the plasma membrane. Cell penetrating peptides (CPPs) are known to transport cargo molecules attached to it into cells. We synthesized intracellular CAs containing known CPPs or modified peptides. Gd-diethylenetriaminepenta-acetic acid (Gd-DTPA) was coupled to CPPs for MR visualization and fluorescence imaging agent fluorescein isothiocyanate (FITC) for tracking the agent inside cells by optical imaging. Compared on the basis of these measurements, modifications in CPPs enhanced the intracellular delivery ability of our CAs providing a tool for stable labeling of cells for MR imaging.