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Hemodynamics and nonlinearities of BOLD response to ultrashort visual stimulation (5ms - 1s)

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons84269

Uludag,  K
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84323

Yesilyurt,  B
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Uludag, K., Yesilyurt, B., & Ugurbil, K. (2006). Hemodynamics and nonlinearities of BOLD response to ultrashort visual stimulation (5ms - 1s). Poster presented at 14th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2006), Seattle, WA, USA.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-D1FF-4
Abstract
It has generally been suggested that one cannot temporally resolve alterations in neural activity in the range of milliseconds using BOLD signal since hemodynamic response evolves in seconds. However, in this study using ultrashort visual stimulus durations ranging from 5 milliseconds to 1 second we investigated the hemodynamic response and nonlinearity of BOLD response. We were able to show that 1) a BOLD response to stimulus durations as short as 5 ms is detectable in humans; b) BOLD responses to different stimulus durations are highly non-linear and c) non-linearities depend not only to stimulus duration but also on intensity.