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Changes in specific metabolic pathways are essential steps in the early apoptotic process in the liver

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons83941

Gottschalk,  S
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Gottschalk, S., Chan TS, Raymond V-A, Bilodeau M, Leibfritz, D., & Zwingmann, C. (2006). Changes in specific metabolic pathways are essential steps in the early apoptotic process in the liver. Poster presented at 14th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2006), Seattle, WA, USA.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-D1FB-C
Abstract
the immunosuppressant Cyclosporine A (CsA), we used multinuclear NMR spectroscopy and molecular studies to characterize metabolic pathways in mice liver during anti-Fas-induced apoptosis. An upregulation of specific metabolic pathways of glucose was the earliest indicator of the effect of Fas on the liver. CsA prevented apoptosis and energy failure at late stages, while the reversal of Fas-induced metabolic upregulation at early stages preceded the protective effect of EGF on programmed cell death. These phenomena provide useful hints for the understanding of early mechanisms controlling apoptotic cell death.