Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
Zur Ablage hinzufügen
  Lokale TagsFreigabegeschichteDetailsÜbersicht

Freigegeben
Zeitschriftenartikel

Determination of arbidol in human plasma by LC-ESI-MS.

MPG-Autoren
Es sind keine MPG-Autoren in der Publikation vorhanden
Externe Ressourcen

https://www.sciencedirect.com/science/article/pii/S0731708506004419
(Verlagsversion)

Volltexte (beschränkter Zugriff)
Für Ihren IP-Bereich sind aktuell keine Volltexte freigegeben.
Volltexte (frei zugänglich)
Es sind keine frei zugänglichen Volltexte in PuRe verfügbar
Ergänzendes Material (frei zugänglich)
Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar
Zitation

Liu, X., Li, J., Huang, W., Li, B., Chen, H., & Bi, S. (2006). Determination of arbidol in human plasma by LC-ESI-MS. Journal of Pharmaceutical and Biomedical Analysis, 43(1), 371-375. doi:10.1016/j.jpba.2006.06.039.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-0013-D07F-E
Zusammenfassung
A sensitive, specific and accurate method for determination of arbidol in human plasma was developed. Arbidol and internal standard were extracted from plasma samples by liquid–liquid extraction with diethyl ether. The chromatographic separation was accomplished on a Shiseido C18 3 amp;956;m analytical column (100 mm × 2.0 mm i.d.) at a flow rate of 0.3 mL/min isocratically. Detection was performed on a single quadrupole mass spectrometer by selected ion monitoring (SIM) mode via electrospray ionization (ESI) source. The method had a chromatographic run time of 6 min and a good linear relationship over the range 1–1000 ng/mL. The limit of quantitation for arbidol in plasma was 1 ng/mL. The intra-day and inter-day precision (R.S.D.) was lower than 7 and accuracy ranged from 95 to 105. The proposed method enables unambiguous identification and quantification of arbidol in vivo and has been successfully applied to study the pharmacokinetics of arbidol in healthy male Chinese volunteers
.