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Combining MRI with invasive neuroscientific techniques: An attempt to study distributed neural networks

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons84063

Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Logothetis, N. (2006). Combining MRI with invasive neuroscientific techniques: An attempt to study distributed neural networks. Talk presented at 23rd Annual Scientific Meeting of the ESMRMB 2006. Warsaw, Poland.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-D01F-4
Abstract
The combination of fMRI with electrophysiology, histology, and neurochemistry promises great insights into a level of neural organization that could have never been studied with either technique alone. My talk will focus on (a) spatially resolved fMRI and MRSI (spectroscopic imaging); (b) the study of in vivo connectivity using fMRI and electrical microstimulation, or manganese-enhanced MRI; (c) combined physiology and MRI for examining the electrical activity occurring during increases and decreases of BOLD activation, and (d) molecular imaging based on smart agents. MRSI optimization enabled sufficiently high spectral dispersion and spatiotemporal resolution to obtain isolated glutamate maps in the primate brain. Ongoing research attempts the differentiation of brain structures in the millimeter range and/or detection of small concentration differences in the same structure (activated vs. non-activated cortex). Finally, I will report our first attempt (a) to develop chelates for Gd and endow them with the appropriate coordinating groups that reversibly block some of the Gd’s free coordination sites with changes in pH or [Ca++].