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Cell-based delivery of oncolytic viruses: a new strategic alliance for a biological strike against cancer

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons84656

Power,  AT
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Power, A. (2007). Cell-based delivery of oncolytic viruses: a new strategic alliance for a biological strike against cancer. Molecular Therapy, 15(4), 660-665. doi:10.1038/sj.mt.6300098.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-CDF5-6
Abstract
Recent years have seen tremendous advances in the development of exquisitely targeted replicating virotherapeutics that can safely destroy malignant cells. Despite this promise, clinical advancement of this powerful and unique approach has been hindered by vulnerability to host defenses and inefficient systemic delivery. However, it now appears that delivery of oncolytic viruses within carrier cells may offer one solution to this critical problem. In this review, we compare the advantages and limitations of the numerous cell lineages that have been investigated as delivery platforms for viral therapeutics, and discuss examples showing how combined cell–virus biotherapeutics can be used to achieve synergistic gains in antitumor activity. Finally, we highlight avenues for future preclinical research that might be taken in order to refine cell–virus biotherapeutics in preparation for human trials.