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Spatial specificity of CBV and BOLD fMRI in monkey striate cortex at 4.7T and 7T

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons84326

Zappe,  A-C
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84063

Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons83937

Goense,  JBM
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Zappe, A.-C., Logothetis, N., & Goense, J. (2007). Spatial specificity of CBV and BOLD fMRI in monkey striate cortex at 4.7T and 7T. Poster presented at 2007 Joint Annual Meeting ISMRM-ESMRMB, Berlin, Germany.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-CDE7-6
Abstract
High resolution fMRI allows us to determine more accurately the origins of the fMRI signal. This has shown that even at high field, the GE-BOLD signal has still a large vascular contribution [1]. Alternative methods like SE- and monocrystalline iron oxide nanocolloid (MION)-based methods have been shown to be spatially more specific than conventional BOLD, and are able to reveal functional subunits in the cortex [2-6]. Here we compare the specificity of BOLD and CBV fMRI methods in the macaque; its striate cortex shows very obvious laminar structure in anatomical images, allowing accurate determination of the precise location of the fMRI activation.