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Metabolic Characterization of Patients with Alcoholic and Non-Alcoholic Steatohepatitis


Gottschalk,  S
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Gottschalk, S., Hohnholt M, Bilodeau M, Leibfritz, D., & Zwingmann, C. (2007). Metabolic Characterization of Patients with Alcoholic and Non-Alcoholic Steatohepatitis. Poster presented at 2007 Joint Annual Meeting ISMRM-ESMRMB, Berlin, Germany.

Liver steatosis is an increasingly common cause of liver diseases. Today it is still difficult to differentiate patients with non-alcoholic steatohepatitis (NASH) from patients with alcoholic steatohepatitis (ASH) on the basis of clinical and biochemical evaluations. Since it is becoming urgent to develop new diagnostic methods for NASH, we applied high-resolution 1H- and (natural abundance) 13C-NMR spectroscopy to detect metabolic profiles in preparations of blood and urine in patients with NASH and ASH. 1H- and 13C-NMR spectra of urine and blood samples showed considerable and reproducible differences in specific metabolites involved in intermediary as well as lipid metabolism in patients with NASH and ASH compared to healthy controls. The results demonstrate that NMR applications on human body fluids are of great potential to characterize NASH, a disease displaying multiple interrelated metabolic factors. This approach could provide noninvasively data to characterize steatosis and give the possibility to distinguish between NASH and ASH.