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Extravascular BOLD Effect for Different Size Blood Vessels Over a Large Range of Magnetic Fields

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons84269

Uludag,  K
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84094

Müller-Bierl,  BM
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Uludag, K., Müller-Bierl, B., & Ugurbil, K. (2007). Extravascular BOLD Effect for Different Size Blood Vessels Over a Large Range of Magnetic Fields. Poster presented at 2007 Joint Annual Meeting ISMRM-ESMRMB, Berlin, Germany.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-CDD7-A
Abstract
The blood oxygenation level dependent (BOLD) signal depends on physiological changes which affect the signal behavior of protons both in the intra- and extravascular tissue space. The functional dependency of the extravascular signal on the oxygenation fraction Y and on cerebral blood volume (CBV) can currently only be evaluated by numerical simulations. We provide analytical expressions for relaxation rates R2* and R2 depending on Y, B0 up to 9.4 T, and CBV for different size cylinders (approx. 3, 6, 20 μm). These results allow to model stimulus evoked BOLD signal changes for GRE and SE at different field strengths.