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Dynamics of Lactate Concentration and BOLD Effect Upon Repeated Identical Visual Stimuli

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons84063

Tkac I, Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Mangia, S., Tkac I, Logothetis, N., Van de Moortele P-F, Gruetter, R., & Ugurbil, K. (2007). Dynamics of Lactate Concentration and BOLD Effect Upon Repeated Identical Visual Stimuli. Poster presented at 2007 Joint Annual Meeting ISMRM-ESMRMB, Berlin, Germany.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-CDD5-E
Abstract
In vivo 1H NM spectroscopy at 7 T was utilized to measure the changes of lactate concentration upon repeated identical visual stimuli, each lasting 2 min. The amplitude of these changes was attenuated from the initial value of 0.2 μmol/g and gradually disappeared in the noise. In sharp contrast, the Blood Oxygen Level Dependent (BOLD) effect was persistent during the whole paradigm. This finding may suggest a differential adaptation of cortical output that is not reflected at the level of the global excitation-inhibition activity of the cortical canonical circuits.