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BOLD sensitivity to cortical activation induced by microstimulation: comparison to visual stimulation

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons83787

Augath,  M
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84063

Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Zitation

Sultan, F., Augath, M., & Logothetis, N. (2007). BOLD sensitivity to cortical activation induced by microstimulation: comparison to visual stimulation. Magnetic Resonance Imaging, 25(6), 754-759. doi:10.1016/j.mri.2007.03.014.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0013-CC93-8
Zusammenfassung
Electrical microstimulation via intracortical electrodes is a widely used method for deducing functions of the brain. In this study, we compared the spatial extent and amplitude of BOLD responses evoked by intracortical electrical stimulation in primary visual cortex with BOLD activations evoked by visual stimulation. The experiments were performed in anesthetized rhesus monkeys. Visual stimulation yielded activities larger than predicted from the well-established visual magnification factor. However, electrical microstimulation yielded an even greater spread of the BOLD response. Our results confirm that the effects of electrical microstimulation extend beyond the brain region expected to be excited by direct current spread.