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Azamacrocyclic Ca2+ Sensitive Contrast Agents for MR Imaging

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Mamedov,  I
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Angelovski,  G
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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SMI-2007-Mamedov.pdf
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Citation

Mamedov, I., Angelovski, G., Henig, J., Mayer, H., & Logothetis, N. (2007). Azamacrocyclic Ca2+ Sensitive Contrast Agents for MR Imaging. Poster presented at AMI/SMI Joint Molecular Imaging Conference 2007, Providence, RI, USA.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-CC13-A
Abstract
As calcium plays an important role in regulating a great variety of neuronal processes, many efforts are already made to generate gadolinium complexes that can act as a calcium-sensors in MRI.1 We developed a series of the DO3A-based macrocyclic and bismacrocyclic gadolinium chelates, bearing phosphonate groups as an additional coordination sites. These complexes are hypothesized to change the MRI contrast dynamically with Ca2+ concentration. Different lengths of the phosphonate side chains are exploited for fine-tuning the sensitivity of the agent to calcium ion concentration.