de.mpg.escidoc.pubman.appbase.FacesBean
English
 
Help Guide Disclaimer Contact us Login
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

In vivo intermolecular zero-quantum coherence MR spectroscopy in the rat spinal cord at 17.6 T: a feasibility study

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons83793

Balla,  DZ
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

Locator
There are no locators available
Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available
Citation

Balla, D. (2007). In vivo intermolecular zero-quantum coherence MR spectroscopy in the rat spinal cord at 17.6 T: a feasibility study. Magnetic Resonance Materials in Physics Biology and Medicine, 20(4), 183-191. doi:10.1007/s10334-007-0081-3.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-CB77-0
Abstract
Objective: The feasibility of in vivo magnetic resonance spectroscopy of the healthy rat spinal cord at 17.6 T using conventional methods and intermolecular zero-quantum coherence (iZQC) spectroscopy is explored and the performance of both approaches is compared. Methods: Localised spectra were acquired at 17.6 T from three healthy Fisher rats and phantoms with injected iron-oxide particles using the PRESS and a modified HOMOGENIZED sequence. Results: Well-resolved in vivo spectra showing the four singlet resonances of creatine, choline, and N-acetyl aspartate were obtained with both approaches. iZQC spectra were acquired from larger voxels, but did not provide higher sensitivity or resolution in the healthy spinal cord. In the presence of paramagnetic iron-oxide particles, the quality of in vitro spectra acquired with PRESS declined and was strongly dependent on the quality of the local shim. iZQC spectra were not affected by the presence of iron-oxide particles and provided narrow lines (9 Hz) independent of the shim. Conclusion: In vivo iZQC spectroscopy of the rat spinal cord is possible. The robustness in presence of local field distortions makes iZQC methods a promising alternative for the investigation of tissue containing labelled cells, implants, or clotted blood. New application of MRS to tissue inaccessible using conventional methods may thus become possible.