de.mpg.escidoc.pubman.appbase.FacesBean
English
 
Help Guide Disclaimer Contact us Login
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

GABA concentrations in the human anterior cingulate cortex predict negative BOLD responses in fMRI

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons84402

Walter M, Schulte RF, Beck J, Dydak U, Henning,  A
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

Locator
There are no locators available
Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available
Citation

Northoff, G., Walter M, Schulte RF, Beck J, Dydak U, Henning, A., Boeker H, Grimm, S., & Boesiger, P. (2007). GABA concentrations in the human anterior cingulate cortex predict negative BOLD responses in fMRI. Nature Neuroscience, 10(12), 1515-1517. doi:10.1038/nn2001.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-CAE5-F
Abstract
The human anterior cingulate cortex (ACC) is part of the default-mode network that shows predominant negative blood oxygen level–dependent (BOLD) responses in functional magnetic resonance imaging (fMRI). We combined fMRI during emotional processing and resting-state magnetic resonance spectroscopy measurements and observed that the concentration of GABA in the ACC specifically correlated with the amount of negative BOLD responses in the very same region. Our findings show that default-mode network negative BOLD responses during emotions are mediated by GABA.