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Synthesis and Characterization of a Smart Contrast Agent Sensitive to Calcium

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons83883

Dhingra,  K
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons83807

Maier ME, Beyerlein,  M
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons83784

Angelovski,  G
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84063

Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Dhingra, K., Maier ME, Beyerlein, M., Angelovski, G., & Logothetis, N. (2008). Synthesis and Characterization of a Smart Contrast Agent Sensitive to Calcium. Chemical Communications, 29, 3444-3446. doi:10.1039/b801975d.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-C8DF-F
Abstract
A novel first-generation Ca2+ sensitive contrast agent, Gd-DOPTRA has been synthesized and characterized. The agent shows 100 relaxivity enhancement upon addition of Ca2+. The agent is selective and sensitive to Ca2+ also in the presence of Mg2+ and Zn2+. The relaxivity studies carried out in physiological fluids prove the prospects of the agent for in vivo measurements.