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Poster

In-vivo T1 and T2* tissue-relaxation rates of H2O17 at 16.4 Tesla

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons84317

Wiesner,  HM
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons83793

Balla,  DZ
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84145

Pohmann,  R
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84269

Uludag,  K
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Zitation

Wiesner, H., Balla, D., Pohmann, R., Chen W, Ugurbil, K., & Uludag, K. (2008). In-vivo T1 and T2* tissue-relaxation rates of H2O17 at 16.4 Tesla. Poster presented at ISMRM Workshop on High-Field Systems and Applications 2008: "Whats special about 7T+?", Toronto, Canada.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0013-C68D-C
Zusammenfassung
The measurement of cerebral metabolic rate of oxygen (CMRO2) via direct NMR detection of the stable oxygen isotope 17O is a promising tool to study alterations in brain activity and pathology. Due to the low natural abundance of 0.037 H2O17, optimized acquisition parameters are crucial for 17O-weigthed MRI of metabolically produced cerebral water. It has been suggested that signal-to-noise ratio increases almost quadratically with B0 due to field-independent quadrupolar interactions of 17O. Thus, in comparison to studies at lower field strengths the increased magnetization available at 16.4 T allows an enhanced spatial resolution and thus for the first time a tissue-specific determination of 17O relaxation.