de.mpg.escidoc.pubman.appbase.FacesBean
Deutsch
 
Hilfe Wegweiser Impressum Kontakt Einloggen
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT

Freigegeben

Zeitschriftenartikel

New coil positioning method for interleaved transcranial magnetic stimulation (TMS)/functional MRI (fMRI) and its validation in a motor cortex study

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons84089

Moisa,  M
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84145

Pohmann,  R
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84257

Thielscher,  A
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

Externe Ressourcen
Es sind keine Externen Ressourcen verfügbar
Volltexte (frei zugänglich)
Es sind keine frei zugänglichen Volltexte verfügbar
Ergänzendes Material (frei zugänglich)
Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar
Zitation

Moisa, M., Pohmann, R., Ewald, L., & Thielscher, A. (2009). New coil positioning method for interleaved transcranial magnetic stimulation (TMS)/functional MRI (fMRI) and its validation in a motor cortex study. Journal of Magnetic Resonance Imaging, 29(1), 189-197. doi:10.1002/jmri.21611.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0013-C5E7-A
Zusammenfassung
Purpose To develop and test a novel method for the coil placement in interleaved Transcranial Magnetic Stimulation(TMS)/fMRI studies. Materials and Methods Initially, a desired TMS coil position at the subject’s head is recorded using a neuronavigation system. Subsequently, a custom-made holding device is used for coil placement inside the MR scanner. The parameters of the device corresponding to the prerecorded position are automatically determined from a fast structural image acquired directly before the experiment. The spatial accuracy of our method was verified on a phantom. Finally, in a study on 5 subjects, the coil was placed above the cortical representation of a hand muscle in M1 and the BOLD responses to short rTMS trains were assessed using EPI recordings. Results The spatial accuracy of our method is in the range of 2.9±1.3(SD) mm. Motor cortex stimulation resulted in robust BOLD activations in motor- and auditory-related brain areas, with the activation in M1 being localized in the hand knob. Conclusion We present a user-friendly method for TMS coil positioning in the MR scanner that exhibits good spatial accuracy and speeds up the setup of the experiment. The motor-cortex study proves the viability of the approach and validates our interleaved TMS/fMRI setup.