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Accurate, localized quantification of white matter perfusion with ASL


Pohmann,  R
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Pohmann, R. (2009). Accurate, localized quantification of white matter perfusion with ASL. Talk presented at ESMRMB 2009 Congress: 26th Annual Meeting. Antalya, Turkey.

Purpose/Introduction: Arterial Spin Labeling (ASL) has become a valuable tool to quantify perfusion in gray matter. However, quantitatively and accurately measuring blood flow in the much less perfused white matter has so far not been possible. This is due to the low perfusion signal, the long transit times in white matter and the unavoidable partial volume effects that arise when white matter pixels of a high-resolution perfusion image are added to obtain the necessary sensitivity [1]. These problems can to a certain degree be avoided by using a single voxel technique to quantify blood flow in a relatively large, but well-defined region. Subjects and Methods: The FAIRPRESS-technique [2] combines a FAIR perfusion module with a single voxel PRESS localization. To avoid partial volume effects, saturation pulses were added to suppress signal contributions from outside the selected region. Arterial signal was suppressed by strong bipolar gradients in all three dimensions. Distal and proximal volumes were saturated to additionally suppress inflowing blood.