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Theoretical and Experimental Evaluation of Continuous Arterial Spin Labeling Techniques

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons84145

Pohmann,  R
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons83838

Budde,  J
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Zitation

Pohmann, R., Budde, J., Auerbach EJ, Adriany, G., & Ugurbil, K. (2010). Theoretical and Experimental Evaluation of Continuous Arterial Spin Labeling Techniques. Magnetic Resononance in Medicine, 63(2), 438-446. doi:10.1002/mrm.22243.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0013-C144-7
Zusammenfassung
Continuous arterial spin labeling (CASL) is known to be the most sensitive ASL technique. To avoid magnetization transfer effects and to overcome hardware limitations, several sequences have been proposed that adiabatically label the inflowing blood. Four of these methods are examined with respect to their sensitivity both theoretically by Bloch equation simulations and experimentally. All sequences were optimized carefully by adjusting their measurement parameters based exclusively on the results of simulations. Perfusion measurements on the human brain obtained at 3 T result in excellent images from all techniques while differences in sensitivity are similar to those expected from the simulations.