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Regional Variations of Metabolite Concentrations in the Rat Brain Assessed with in vivo 1H MR Spectroscopy at 16.4T

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons83980

Hong,  S-T
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons83793

Balla,  DZ
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84213

Shajan,  G
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84145

Pohmann,  R
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Hong, S.-T., Balla, D., Shajan, G., Choi, C., & Pohmann, R. (2010). Regional Variations of Metabolite Concentrations in the Rat Brain Assessed with in vivo 1H MR Spectroscopy at 16.4T. Poster presented at ISMRM-ESMRMB Joint Annual Meeting 2010, Stockholm, Sweden.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-C094-C
Abstract
Regional differences of metabolites in the rat brain were investigated by using localized in vivo 1H MR spectroscopy at 16.4T. Three regions, thalamus, striatum and hippocampus, were investigated with an ultra-short TE STEAM sequence. The results demonstrated significant variations in all metabolites except aspartate and NAA. The remarkable variation of spectra was the substantially decreased level of the Tau methylene signal at 3.25 ppm in thalamus. The significant increase of the GABA methylene signal at 1.89 ppm was also observed in thalamus.