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Measurement of the Effects of Different Anesthetics in the Rat Thalamus by in Vivo 1H NMR Spectroscopy at 16.4T

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons83980

Hong,  S-T
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84145

Pohmann,  R
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Hong, S.-T., Choi, C.-B., & Pohmann, R. (2010). Measurement of the Effects of Different Anesthetics in the Rat Thalamus by in Vivo 1H NMR Spectroscopy at 16.4T. Poster presented at ISMRM-ESMRMB Joint Annual Meeting 2010, Stockholm, Sweden.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-C08A-4
Abstract
The effect of different anesthetic agents was investigated in the rat brain by using in vivo 1H NMR spectroscopy. A volume-of-interest was placed in thalamus under two different anesthesia, isoflurane and ketamine/xylazine. The significant increase of glucose was observed in a deep ketamine/xylazine anesthesia while additional metabolic variations on ascorbate, aspartate, glutathione and lactate were detected.