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Gadoxane: a Novel Degradable Silsesquioxane Based Macromolecular MRI Contrast Agent

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons83903

Engelmann,  J
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons83941

Henig J, Gottschalk,  S
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Engelmann, J., Henig J, Gottschalk, S., & Mayer, H. (2010). Gadoxane: a Novel Degradable Silsesquioxane Based Macromolecular MRI Contrast Agent. Poster presented at ISMRM-ESMRMB Joint Annual Meeting 2010, Stockholm, Sweden.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-C078-C
Abstract
Silsesquioxane-based macromolecular MRI-contrast agents have recently been reported to have a compact globular structure resulting in significantly higher relaxivities when compared to smaller MRI-probes. The stability of the core under physiological conditions is unknown so far. We therefore studied the stability of Gadoxane, a new silsesquioxane-based contrast agent connected to eight DOTAGA-gadolinium chelates. The silsesquioxane core was almost completely hydrolyzed under physiological conditions while the integrity of the gadolinium chelate was maintained. In conclusion, these probes cannot be considered as stable anymore. However, their degradability might improve their in vivo-applicability due to a faster renal excretion of the smaller fragments.