de.mpg.escidoc.pubman.appbase.FacesBean
English
 
Help Guide Disclaimer Contact us Login
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

In-vivo assessment of tissue metabolite levels using 1H MRS and the Electric REference To access In vivo Concentrations (ERETIC) method

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons84402

De Zanche N, Pavan M, Mens G, Sturzenegger U, Henning,  A
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

Locator
There are no locators available
Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available
Citation

Heinzer-Schweizer, S., De Zanche N, Pavan M, Mens G, Sturzenegger U, Henning, A., & Boesiger, P. (2010). In-vivo assessment of tissue metabolite levels using 1H MRS and the Electric REference To access In vivo Concentrations (ERETIC) method. NMR in Biomedicine, 23(4), 406–413. doi:10.1002/nbm.1476.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-C01E-5
Abstract
Quantitative values of metabolite concentrations in 1H magnetic resonance spectroscopy have been obtained using the Electric REference To access Invivo Concentrations (ERETIC) method, whereby a synthetic reference signal is injected during the acquisition of spectra. The method has been improved to enable quantification of metabolite concentrations invivo. Optical signal transmission was used to eliminate random fluctuations in ERETIC signal coupling to the receiver coil due to changes in position of cables and highly dielectric human tissue. Stability and reliability of the signal were tested in vitro, achieving stability with a mean error of 2.83. Scaling of the signal in variable loading conditions was demonstrated and in-vivo measurements of brain were acquired on a 3T Philips system using a transmit/receive coil. The quantitative brain water and metabolite concentration values are in good agreement with those in the literature.