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Journal Article

Millisecond encoding precision of auditory cortex neurons

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons84006

Kayser,  C
Research Group Physiology of Sensory Integration, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Research Group Physiology of Sensory Integration, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84063

Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84966

Panzeri,  S
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Kayser, C., Logothetis, N., & Panzeri, S. (2010). Millisecond encoding precision of auditory cortex neurons. Proceedings of the National Academy of the United States of America, 107(39), 16976-16981. doi:10.1073/pnas.1012656107.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-BE52-9
Abstract
Neurons in auditory cortex are central to our perception of sounds. However, the underlying neural codes, and the relevance of millisecond precise spike timing in particular, remain debated. Here we addressed this issue in the auditory cortex of alert non-human primates by quantifying the amount of information carried by precise spike timing about complex sounds presented for extended periods of time (random tone sequences and natural sounds). We investigated the dependence of stimulus information on the temporal precision at which spike times were registered, and found that registering spikes at a precision coarser than a few milliseconds significantly reduced the encoded information. This demonstrates that auditory cortex neurons can carry stimulus information at high temporal precision. In addition, we found that the main determinant of finely timed information was rapid modulation of the firing rate, while higher-order correlations between spike times contributed negligibly. While the neural coding precis ion was high for random tone sequences and natural sounds, the information lost at a precision coarser than a few milliseconds was higher for the stimulus sequence that varied on a faster time scale (random tones), suggesting that the precision of cortical firing depends on the stimulus dynamics. Together, these results provide a neural substrate for recently reported behavioral relevance of precisely timed activity patterns with auditory cortex. In addition, they highlight the importance of millisecond precise neural coding as general functional principle of auditory processing – from the periphery to cortex.