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Electroconvulsive therapy resolves cortical inhibition and manneristic omissions in a chronic catatonic patient

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons83933

Giani,  AS
Research Group Cognitive Neuroimaging, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department Human Perception, Cognition and Action, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Zitation

Dresler, T., Giani, A., Reinsberger C, Scheuerpflug P, Stöber, G., & Fallgatter, A. (2010). Electroconvulsive therapy resolves cortical inhibition and manneristic omissions in a chronic catatonic patient. Journal of Neural Transmission, 117(10), 1209-1212. doi:10.1007/s00702-010-0467-7.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0013-BDBC-5
Zusammenfassung
We investigated a patient with severe catatonic schizophrenia (manneristic catatonia according to Karl Leonhard) treated with electroconvulsive therapy (ECT) after pharmacological approaches did not result in any clinical improvement. Before and after nine ECT sessions a double-pulse transcranial magnetic stimulation (TMS) paradigm was used to measure intracortical inhibition (ICI) which has been shown to be reduced in a significant proportion of patients with schizophrenia. Although the patient showed no remission regarding some psychomotor aspects after ECT, we found an increase in ICI and a remarkable clinical improvement of catatonic omissions which might be due to changes in the GABAergic system.