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Accurate, localized quantification of white matter perfusion with single-voxel ASL

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons84145

Pohmann,  R
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Zitation

Pohmann, R. (2010). Accurate, localized quantification of white matter perfusion with single-voxel ASL. Magnetic Resonance in Medicine, 64(4), 1109-1113. doi:10.1002/mrm.22476.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0013-BDAE-5
Zusammenfassung
Quantification of perfusion in white matter is still difficult due to its low level, causing an often insufficiently low signal-to-noise ratio, and its long and inhomogeneous transit delays. Here, a technique is presented that accurately measures white matter perfusion by combining a spectroscopic single-voxel localization technique (PRESS) with a pulsed arterial spin labeling encoding scheme (FAIR) to specifically address the properties of white matter. The transit delay was measured by shifting the position of a slice-selective saturation pulse between inversion and acquisition. Perfusion measurements resulted in values of 15.6 ± 3.2 ml/100g/min in the left and 15.2 ± 4.8 ml/100g/min in the right hemispheric white matter and 83.2 ± 15.2 ml/100g/min in cortical gray matter. Taking dispersion of the transit times into account does not cause a significant change in the measured values.