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In Vivo Characterization of a Smart MRI Agent That Displays an Inverse Response to Calcium Concentration

MPG-Autoren
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Mamedov,  I
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Canals,  S
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Beyerlein,  M
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Murayama,  Y
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Angelovski,  G
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

Externe Ressourcen

https://pubs.acs.org/doi/ipdf/10.1021/cn100083a
(Verlagsversion)

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Zitation

Mamedov, I., Canals, S., Henig, J., Beyerlein, M., Murayama, Y., Mayer, H., et al. (2010). In Vivo Characterization of a Smart MRI Agent That Displays an Inverse Response to Calcium Concentration. ACS Chemical Neuroscience, 1(12), 819-828. doi:10.1021/cn100083a.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-0013-BD20-3
Zusammenfassung
Contrast agents for magnetic resonance imaging (MRI) that exhibit sensitivity toward specific ions or molecules represent a challenging but attractive direction of research. Here a Gd3+ complex linked to an aminobis(methylenephosphonate) group for chelating Ca2+ was synthesized and investigated. The longitudinal relaxivity (r1) of this complex decreases during the relaxometric titration with Ca2+ from 5.76 to 3.57 mMamp;amp;8722;1 samp;amp;8722;1 upon saturation. The r1 is modulated by changes in the hydration number, which was confirmed by determination of the luminescence emission lifetimes of the analogous Eu3+ complex. The initial in vivo characterization of this responsive contrast agent was performed by means of electrophysiology and MRI experiments. The investigated complex is fully biocompatible, having no observable effect on neuronal function after administration into the brain ventricles or parenchyma. Distribution studies demonstrated that the diffusivity
of this
agent is
significantly lower compared with that of gadoliniumamp;amp;8722;diethylenetriaminepentaacetic acid (Gdamp;amp;8722;DTPA).