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In Vivo Characterization of a Smart MRI Agent That Displays an Inverse Response to Calcium Concentration

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons84074

Mamedov,  I
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84751

Canals,  S
Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons83807

Henig J, Beyerlein,  M
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84099

Murayama,  Y
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84063

Mayer HA, Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons83784

Angelovski,  G
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Mamedov, I., Canals, S., Henig J, Beyerlein, M., Murayama, Y., Mayer HA, Logothetis, N., & Angelovski, G. (2010). In Vivo Characterization of a Smart MRI Agent That Displays an Inverse Response to Calcium Concentration. ACS Chemical Neuroscience, 1(12), 819-828. doi:10.1021/cn100083a.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-BD20-3
Abstract
Contrast agents for magnetic resonance imaging (MRI) that exhibit sensitivity toward specific ions or molecules represent a challenging but attractive direction of research. Here a Gd3+ complex linked to an aminobis(methylenephosphonate) group for chelating Ca2+ was synthesized and investigated. The longitudinal relaxivity (r1) of this complex decreases during the relaxometric titration with Ca2+ from 5.76 to 3.57 mMamp;amp;8722;1 samp;amp;8722;1 upon saturation. The r1 is modulated by changes in the hydration number, which was confirmed by determination of the luminescence emission lifetimes of the analogous Eu3+ complex. The initial in vivo characterization of this responsive contrast agent was performed by means of electrophysiology and MRI experiments. The investigated complex is fully biocompatible, having no observable effect on neuronal function after administration into the brain ventricles or parenchyma. Distribution studies demonstrated that the diffusivity of this agent is significantly lower compared with that of gadoliniumamp;amp;8722;diethylenetriaminepentaacetic acid (Gdamp;amp;8722;DTPA).