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Critical In Vitro Evaluation of Responsive MRI Contrast Agents for Calcium and Zinc

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons84084

Mishra,  A
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84063

Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Zitation

Mishra, A., Logothetis, N., & Parker, D. (2011). Critical In Vitro Evaluation of Responsive MRI Contrast Agents for Calcium and Zinc. Chemistry: A European Journal, 17(5), 1529-1537. doi:10.1002/chem.201001548.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0013-BC86-7
Zusammenfassung
The synthesis of two gadolinium(III) complexes that exhibit an increase in proton relaxivity in the presence of added Ca2+ or Zn2+ ions is reported. The complexes increase their hydration state from zero to one following metal-ion binding, confirmed by spectral measurements on the corresponding EuIII complexes. At a field of 1.48197;T and 3108197;K, modulation of relaxivity of the order of 30–408201; was observed in mouse serum in each case. The dissociation constants for Ca2+ and Zn2+ binding were sensitive to the presence of added bicarbonate, and were 4508197;956;M (Ca2+) and 2008197;956;M (Zn2+) in serum. Such systems may, therefore, be considered for use as magnetic resonance imaging (MRI) contrast agents to track the restoration of changes in metal-ion concentration in the cerebrospinal fluid of the brain, following neural stimulation.