de.mpg.escidoc.pubman.appbase.FacesBean
English
 
Help Guide Disclaimer Contact us Login
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Critical In Vitro Evaluation of Responsive MRI Contrast Agents for Calcium and Zinc

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons84084

Mishra,  A
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84063

Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

Locator
There are no locators available
Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available
Citation

Mishra, A., Logothetis, N., & Parker, D. (2011). Critical In Vitro Evaluation of Responsive MRI Contrast Agents for Calcium and Zinc. Chemistry: A European Journal, 17(5), 1529-1537. doi:10.1002/chem.201001548.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-BC86-7
Abstract
The synthesis of two gadolinium(III) complexes that exhibit an increase in proton relaxivity in the presence of added Ca2+ or Zn2+ ions is reported. The complexes increase their hydration state from zero to one following metal-ion binding, confirmed by spectral measurements on the corresponding EuIII complexes. At a field of 1.48197;T and 3108197;K, modulation of relaxivity of the order of 30–408201; was observed in mouse serum in each case. The dissociation constants for Ca2+ and Zn2+ binding were sensitive to the presence of added bicarbonate, and were 4508197;956;M (Ca2+) and 2008197;956;M (Zn2+) in serum. Such systems may, therefore, be considered for use as magnetic resonance imaging (MRI) contrast agents to track the restoration of changes in metal-ion concentration in the cerebrospinal fluid of the brain, following neural stimulation.