English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
  Local TagsRelease HistoryDetailsSummary

Released
Journal Article

Critical In Vitro Evaluation of Responsive MRI Contrast Agents for Calcium and Zinc

MPS-Authors
/persons/resource/persons84084

Mishra,  A
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons84063

Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

External Resource

https://onlinelibrary.wiley.com/doi/epdf/10.1002/chem.201001548
(Publisher version)

Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Mishra, A., Logothetis, N., & Parker, D. (2011). Critical In Vitro Evaluation of Responsive MRI Contrast Agents for Calcium and Zinc. Chemistry: A European Journal, 17(5), 1529-1537. doi:10.1002/chem.201001548.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-BC86-7
Abstract
The synthesis of two gadolinium(III) complexes that exhibit an increase in proton relaxivity in the presence of added Ca2+ or Zn2+ ions is reported. The complexes increase their hydration state from zero to one following metal-ion binding, confirmed by spectral measurements on the corresponding EuIII complexes. At a field of 1.48197;T and 3108197;K, modulation of relaxivity of the order of 30–408201; was observed in mouse serum in each case. The dissociation constants for Ca2+ and Zn2+ binding were sensitive to the presence of added bicarbonate, and were 4508197;956;M (Ca2+) and 2008197;956;M (Zn2+) in serum. Such systems may, therefore, be considered for use as magnetic resonance imaging (MRI) contrast agents to track the restoration of changes in metal-ion concentration in the cerebrospinal fluid of the brain, following neural stimulation.