Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
Zur Ablage hinzufügen
  Lokale TagsFreigabegeschichteDetailsÜbersicht

Freigegeben
Poster

The effect of a pharmacological ketamine challenge on working memory and brain metabolism

MPG-Autoren
Es sind keine MPG-Autoren in der Publikation vorhanden
Externe Ressourcen

https://www.sciencedirect.com/science/article/pii/S000632231100309X
(Verlagsversion)

Volltexte (beschränkter Zugriff)
Für Ihren IP-Bereich sind aktuell keine Volltexte freigegeben.
Volltexte (frei zugänglich)
Es sind keine frei zugänglichen Volltexte in PuRe verfügbar
Ergänzendes Material (frei zugänglich)
Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar
Zitation

Scheidegger, M., Boeker, H., Seifritz, E., Boesiger, P., Bajbouj, M., Walter, M., et al. (2011). The effect of a pharmacological ketamine challenge on working memory and brain metabolism. Poster presented at 66th Society of Biological Psychiatry Annual Meeting 2011, San Francisco, CA, USA.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-0013-BC0C-A
Zusammenfassung
Background / Purpose:
Ketamine is a potent glutamatergic NMDA receptor antagonist with rapid antidepressant properties at subanaesthetic doses, thus providing a valuable research tool for the investigation of the neurobiology of mood disorders. Increasing evidence under-scores the role of glutamate dependent neuroplasticity and glutamatergic neurotransmission and metabolism in the patho-physiology of major depressive disorder.Hence, the effects of ketamine on functional brain activity during emotional and cognitive processing have to be further investigated in order to understand its rapid antidepressant properties.
This imaging study in 14 healthy subjects aims at probing the neuropharmacological effects of a single intravenous subanaesthetic ketamine infusion on fMRI-BOLD responses during a working memory task using affective stimuli compared to baseline conditions.
Main conclusion:
Ketamine administration had no effect on working memory performance, accordingly neural activity in the DLPFC did not differ between the baseline and the ketamine session. However, there was a significant ketamine effect on negative BOLD- responses in anterior (pregenual anterior cingulate), but not posterior (posterior cingulate) regions of the default- mode network and thus seems to induce a decoupling of neural activity in anterior and posterior regions of the network.