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Measurement of CMRO2 changes by somatosensory stimulation in rat using oxygen-17 at 16.4 T

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons84317

Wiesner,  HM
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84145

Pohmann,  R
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons83793

Balla,  DZ
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84269

Uludag,  K
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Wiesner, H., Pohmann, R., Balla, D., Chen W, Ugurbil, K., & Uludag, K. (2011). Measurement of CMRO2 changes by somatosensory stimulation in rat using oxygen-17 at 16.4 T. Poster presented at 19th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2011), Montréal, Canada.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-BC04-9
Abstract
We have observed the first directly measured CMRO2 changes in rats by peripheral somatosensory stimulation at an ultrahigh field strength of 16.4 Tesla. The results show that apart from the high sensitivity required also the stability of baseline metabolism is crucial in detecting small CMRO2 changes evoked by increased neural activity. Lower global baseline metabolism was found when ventilating with a N2O vs. N2 mixture of equal O2 fraction due to the increased anesthetic effect of N2O in agreement with previous work. The direct detection of changes in CMRO2 can also help to investigate the metabolic changes in negative BOLD activations on the ipsilateral hemisphere. Our results are also in accordance with previous results using 17O for CMRO2 measurements from other species at 9.4T.