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Emotional Processing And Brain Metabolism After Pharmacological Stimulation With Ketamine

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons84402

Henning,  A
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Scheidegger, M., Grimm S, Fuchs A, Kraehenmann R, Boeker H, Seifritz E, Boesiger P, Walter, M., & Henning, A. (2011). Emotional Processing And Brain Metabolism After Pharmacological Stimulation With Ketamine. Poster presented at 19th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2011), Montréal, Canada.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-BBF4-6
Abstract
Ketamine is a potent glutamatergic NMDA receptor antagonist with rapid antidepressant properties at subanaesthetic doses, thus providing a valuable research tool for the investigation of the neurobiology of major depressive disorder (MDD). This multimodal imaging study in 14 healthy subjects reveals the neuropharmacological effects of a single intravenous subanaesthetic ketamine infusion on fMRI-BOLD responses during an emotional processing task and their relationship to glutamatergic metabolite concentrations in the pregenual anterior cingulate cortex (PACC) assessed by proton magnetic resonance spectroscopy (1H-MRS) and indicates a close relationship between BOLD reactivity and glutamatergic metabolism after pharmacological stimulation.