Emotional Processing And Brain Metabolism After Pharmacological Stimulation 
With Ketamine

Scheidegger, M; Grimm, S; Fuchs, A; Kraehenmann, R; Boeker, H; Seifritz, E; Boesiger, P; Walter, M; Henning, A

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Meeting Abstract

Emotional Processing And Brain Metabolism After Pharmacological Stimulation With Ketamine

MPS-Authors

There are no MPG-Authors in the publication available

External Resource

https://cds.ismrm.org/protected/11MProceedings/files/1_program.htm
(Abstract)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Scheidegger, M., Grimm, S., Fuchs, A., Kraehenmann, R., Boeker, H., Seifritz, E., et al. (2011). Emotional Processing And Brain Metabolism After Pharmacological Stimulation With Ketamine. In 19th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2011).

Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-BBF4-6

Abstract

Ketamine is a potent glutamatergic NMDA receptor antagonist with rapid antidepressant properties at subanaesthetic doses, thus providing a valuable research tool for the investigation of the neurobiology of major depressive disorder (MDD). This multimodal imaging study in 14 healthy subjects reveals the neuropharmacological effects of a single intravenous subanaesthetic ketamine infusion on fMRI-BOLD responses during an emotional processing task and their relationship to glutamatergic metabolite concentrations in the pregenual anterior cingulate cortex (PACC) assessed by proton magnetic resonance spectroscopy (1H-MRS) and indicates a close relationship between BOLD reactivity and glutamatergic metabolism after pharmacological stimulation.