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Cation-Responsive MRI Contrast Agents Based on Gadolinium(III)

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons83784

Angelovski,  G
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84074

Mamedov,  I
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Angelovski, G., & Mamedov, I. (2011). Cation-Responsive MRI Contrast Agents Based on Gadolinium(III). Current Inorganic Chemistry, 1(1), 76-90. doi:10.2174/1877944111101010076.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-BBA6-7
Abstract
Magnetic resonance imaging (MRI) offers the ability to visualize a number of biological processes at the molecular and cellular level. The quest for MRI methods that enable the monitoring of these processes with improved specificity and spatiotemporal resolution has induced a considerable amount of research into the chemistry of contrast agents. A novel class of agents has been developed that is able to report a change in its magnetic properties as a function of a specific parameter in the surrounding microenvironment. The vast majority consist of paramagnetic Gd3+ complexes that enhance the contrast in the MR image upon a change in the local concentration of a biologically relevant ion, such as H+, Ca2+, Zn2+, or Cu2+. This review summarizes their coordination chemistry and further aspects of these responsive paramagnetic complexes and discusses the most recent examples that are described in the literature.