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Journal Article

Structure-related variable responses of calcium sensitive MRI probes

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons84074

Mamdedov,  I
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84063

Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons83784

Angelovski,  G
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Mamdedov, I., Logothetis, N., & Angelovski, G. (2011). Structure-related variable responses of calcium sensitive MRI probes. Organic Biomolecular Chemistry, 9(16), 5816-5824. doi:10.1039/C1OB05463E.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-BB12-2
Abstract
A new series of Gd3+ complexes based on DO3A (GdL1–GdL4) was synthesized and investigated. They possess side chains with different structures which determine their varying binding properties and response towards endogenous metal ions, measured by changes in the longitudinal relaxivity (r1). GdL4 exhibits the highest selectivity toward Ca2+ in comparison to the other complexes, with up to a 63 increase of the r1. GdL2 and GdL3 also respond to different Ca2+ concentration ranges, however with a lower selectivity since the r1 changes are also observed in the presence of other cations such as Mg2+, Zn2+ or Cu2+. Assessment of the hydration number (q) via luminescence lifetime measurements confirmed that the change in q is responsible for the r1 response for all the complexes.