de.mpg.escidoc.pubman.appbase.FacesBean
English
 
Help Guide Disclaimer Contact us Login
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Sensory experience restructures thalamocortical axons during adulthood

MPS-Authors
http://pubman.mpdl.mpg.de/cone/persons/resource/persons84910

Oberlaender,  M
Max Planck Institute for Biological Cybernetics, Max Planck Society;

Locator
There are no locators available
Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available
Citation

Oberlaender, M., Ramirez, A., & Bruno, R. (2012). Sensory experience restructures thalamocortical axons during adulthood. Neuron, 74(4), 648–655. doi:10.1016/j.neuron.2012.03.022.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-B770-1
Abstract
The brain's capacity to rewire is thought to diminish with age. It is widely believed that development stabilizes the synapses from thalamus to cortex and that adult experience alters only synaptic connections between cortical neurons. Here we show that thalamocortical (TC) inputs themselves undergo massive plasticity in adults. We combined whole-cell recording from individual thalamocortical neurons in adult rats with a recently developed automatic tracing technique to reconstruct individual axonal trees. Whisker trimming substantially reduced thalamocorticalaxon length in barrel cortex but not the density of TC synapses along a fiber. Thus, sensoryexperience alters the total number of TC synapses. After trimming, sensory stimulation evoked more tightly time-locked responses among thalamorecipient layer 4 cortical neurons. These findings indicate that thalamocortical input itself remains plastic in adulthood, raising the possibility that the axons of other subcortical structures might also remain in flux throughout life.