de.mpg.escidoc.pubman.appbase.FacesBean
Deutsch
 
Hilfe Wegweiser Impressum Kontakt Einloggen
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT

Freigegeben

Vortrag

Ketamine administration reduces limbic reactivity during emotional stimulation: An fMRI study in healthy subjects

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons84402

Henning,  A
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

Externe Ressourcen
Es sind keine Externen Ressourcen verfügbar
Volltexte (frei zugänglich)
Es sind keine frei zugänglichen Volltexte verfügbar
Ergänzendes Material (frei zugänglich)
Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar
Zitation

Scheidegger, M., Grimm S, Walter M, Boeker H, Boesiger P, Seifritz, E., & Henning, A. (2012). Ketamine administration reduces limbic reactivity during emotional stimulation: An fMRI study in healthy subjects. Talk presented at 20th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2012). Melbourne, Australia.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0013-B750-9
Zusammenfassung
Many neuroimaging findings are compatible with the hypothesis that limbic hyperactivity during evaluation of emotional stimuli, combined with prefrontal hypoactivity, might cause negative emotional biases in patients suffering from major depressive disorder (MDD) and that this imbalance can be reversed by antidepressant drug treatment. Our findings show that in healthy subjects an antidepressant intravenous dose of ketamine reduces limbic reactivity in the amygdalo-hippocampal complex during an emotional processing task, which is in support of the hypothesis that pharmacologically modulating limbic neurocircuits might be an important therapeutic strategy to restore parts of the disrupted neurobehavioural homeostasis in MDD.