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Simultaneous single-quantum and triple-quantum-filtered MRI of 23Na (SISTINA)

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons84405

Romanzetti S, Mirkes,  CC
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Zitation

Fiege, D., Romanzetti S, Mirkes, C., Brenner, D., & Shah, N. (2012). Simultaneous single-quantum and triple-quantum-filtered MRI of 23Na (SISTINA). Magnetic Resonance in Medicine, Epub ahead. doi:10.1002/mrm.24417.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0013-B6BA-5
Zusammenfassung
The low MR sensitivity of the sodium nucleus and its low concentration in the human body constrain acquisition time. The use of both single-quantum and triple-quantum sodium imaging is, therefore, restricted. In this work, we present a novel MRI sequence that interleaves an ultra-short echo time radial projection readout into the three-pulse triple-quantum preparation. This allows for simultaneous acquisition of tissue sodium concentration weighted as well as triple-quantum filtered images. Performance of the sequence is shown on phantoms. The method is demonstrated on six healthy informed volunteers and is applied to three cases of brain tumors. A comparison with images from tumor specific O-(2-[18F]fluoroethyl)-L-tyrosine positron emission tomography and standard MR images is presented. The combined information of the triple-quantum-filtered images with single-quantum images may enable a better understanding of tissue viability. Future studies can benefit from the evaluation of both contrasts with shortened acquisition times.