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A smart 19F and 1H MRI probe with self-immolative linker as a versatile tool for detection of enzymes

MPG-Autoren
http://pubman.mpdl.mpg.de/cone/persons/resource/persons83836

Keliris,  A
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84074

Mamedov,  I
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons83952

Hagberg,  GE
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84063

Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons84187

Scheffler,  K
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

http://pubman.mpdl.mpg.de/cone/persons/resource/persons83903

Engelmann,  J
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Zitation

Keliris, A., Mamedov, I., Hagberg, G., Logothetis, N., Scheffler, K., & Engelmann, J. (2012). A smart 19F and 1H MRI probe with self-immolative linker as a versatile tool for detection of enzymes. Contrast Media and Molecular Imaging, 7(5), 478–483. doi:10.1002/cmmi.1470.


Zitierlink: http://hdl.handle.net/11858/00-001M-0000-0013-B612-0
Zusammenfassung
Here we report on a dual-modal 19F and 1H MRI paramagnetic probe with a self-immolative linker, Gd–DOMF–Gal. The enzymatic conversion of this probe by β-galactosidase resulted in a simultaneous turning on of the fluorine signal and changed ability of the Gd3+ complex to modulate the 1H MR signal intensity of the surrounding water molecules. A versatile imaging platform for monitoring a variety of enzymes by 19F and 1H MRI using this molecular design is proposed.