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Journal Article

Fast metabolite mapping in the pig heart after injection of hyperpolarized 13C-pyruvate with low-flip angle balanced steady-state free precession imaging

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http://pubman.mpdl.mpg.de/cone/persons/resource/persons84187

Scheffler,  K
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Mansson, S., Petersson, J., & Scheffler, K. (2012). Fast metabolite mapping in the pig heart after injection of hyperpolarized 13C-pyruvate with low-flip angle balanced steady-state free precession imaging. Magnetic Resonance in Medicine, 68(6), 1894–1899. doi:10.1002/mrm.24183.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0013-B53E-7
Abstract
The conversion of hyperpolarized 13C pyruvate to metabolic products in the Krebs cycle provides valuable information about the metabolic status and the viability of the myocardium. Therefore, imaging methods must be able to spectrally discriminate different 13C metabolites. However, the requirement for spectral selectivity conflicts with the demands for rapid image acquisition and high spatial resolution in cardiac imaging. In this work, the feasibility of a balanced steady state free precession sequence with low flip angles was investigated in the pig heart after injection of hyperpolarized 13C1-pyruvate. Using cardiac gating, it was possible to acquire 13C-bicarbonate images within a single heartbeat (acquisition time 150 ms) without destroying the substrate signal from the hyperpolarized pyruvate. Therefore, the technique may be useful in dynamic studies of cardiac metabolism.